As the chief and founder of the Clinical Informatics Research Division of the University of Texas Health at San Antonio, I lead a full-spectrum biomedical informatics program and explore the intersection between informatics, translational science, and clinically relevant data-centric problems including, but not limited to, computable phenotype-based research in health disparities, obesity, amyotrophic lateral sclerosis, ageing, and cancer. Under the umbrella of PCORI awards, I created an information system for interdisciplinary collaboration between pediatric endocrinologists, cancer researchers and neurologists, creating new institutional governance frameworks along the way. I also co-direct the informatics core at the Claude Pepper Older Americans Independence Center, a National Institute on Aging award, where I work on state of the art informatics infrastructures to investigate innovative interventions that target the aging process as well as aging-related diseases, with a major focus on pharmacologic interventions. I previously served at Emory University School of Medicine as Associate Director for the Biomedical Informatics Core at the Center for AIDS Research at the Rollins School of Public Health. I also served as Scientific Member of the Winship Cancer Institute Prevention and Control Program and Senior Member of the Research Staff at the Center for Comprehensive Informatics.