Improving effectiveness and safety of patient care is an ultimate objective for medical cyber-physical systems. Many medical best practice guidelines exist in the format of hospital handbooks which are often lengthy and difficult for medical staff to remember and apply clinically. Statechart is an effective tool to model medical guidelines and enables clinical validation with medical staffs. However, some advanced statechart elements could result in high cost, such as low understandability, high difficulty in clinical validation, formal verification, and failure trace back.

Although many studies investigate the automatic adaptation in serious games with the goal to improve the user's motivation, the most part of Affective Computing approaches requires a high development cost and usually does not consider an intervention of health professionals in the control of adaptations that will be executed in a game. This paper describes an approach to enable affective adaptation in serious games for motor rehabilitation with the involvement of physiotherapists.